This thought has also crossed my mind at some point. Along with the problems listed above, there is also no solid way of knowing which of the six bullets are which if alternated, especially if you were in a hurry or stressful situation. A wheel full of .38 for the first 5 rounds and having a .357 as the last and sixth shot sounds kind of enticing, but there really is no practical reason for this. Even if practiced in this particular sequence, a set-up like this would likely have a hard time earning any merit.
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"Vegetarian, an old Indian word for bad hunter."
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