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Any shotgun blast will be devastating to an unarmored human at point-blank range with just about any number shot. (Try it out on test media if you don't believe me.)
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What do you consider "test media?" I guess I'm one of those people would really prefer to not use birdshot for defense.
There are .410 loads out there that shoot five 000 pellets at a listed 1135 fps. I think 000 is something like .36" and 70 grains each. I suspect it could be pretty effective at the right distances, but it may overpenetrate more that desired.
I believe ammo tests have shown that, with proper ammo selection, .223/5.56 will actually be less dangerous in terms of penetrating walls than shotgun and handgun ammo.
I think a .410 could be decent for defense, but there are several others options I'd take first.