44... what took you so long
I have a collection of Automags ( not a 44 Auto Mag yet though ) my Automag 2 shoots 22 magnum... my Automag 3 shoots 30 Carbine, my Automag 4 shoots 10mm magnum, & my Automag 5 shoots 50 A.E. ( BTW... the Automag 5 is the lightest weight of the autos ever chambered for 50 A.E., but houses a ported barrel & slide... which make the concussion from firing, even more "big" )
my "5" with the slide back showing the ports...
as far as the 460 / 500 length cartridge, it's both too powder full for a "normal semi auto design" ( the Desert Eagle uses a rotating bolt ) & the cartridges are too long to fit in a grip mounted magazine, the gun would have to be designed like a Scorpion or Broom Handle, with the magazine either in front ( most practical from a design point of view ), or behind the grip... you would lose a lot of the balance, I wouldn't want to shoot a Broomhandle Mauser chambered in 500 S&W