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If the main question is "What would I buy my wife" not some hypothetical female, but my wife, the answer is easy, a semi-auto .22. I know the .22 is under powered and not recommended by most knowledgeable shooters for self-defense, but as Jim Quinn of gunblast.com likes to say "a .22 is better than a sharp stick" when it comes SD. And if a .22 is the only gun she will shoot and practice with on a regular basis, then a .22 it shall be.
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