Burbank, about the only disadvantage to the two cavity Lee molds is it just takes longer to case a lot of bullets whereas you can really crank them out with the six cavity molds. All my Lee rifle bullet molds are two cavity and I've only had to replace one in the past ten years and I'm pretty sure I cast more than 5K bullets with it.
I have around 40 bullet molds twenty-five of them being Lee, a couple old Lyman / Ideal molds, and several from NOE, Arsenal and Accurate and have nothing bad to say about any of them. If I end up replacing any of my Lee pistol mold in the future it will be with the six cavity molds.
Some powder coated 9 mm Lee 120 gr. TC and Lee 230 gr. 24 ACP bullets I cast and powder coated a couple of weeks ago from my Lee six cavity molds.