I have the full size px4 in 9mm and have the medium backstrap on it. My girlfriend has shot it a few times and didn't have any problems with it being too big. She's 5'0" and has pretty small hands. It is the only gun she's fired so she has nothing to compare it to, but she says it is comfortable to hold.
I'd say as long as your friend liked the gun and after at least dry firing it has no problem reaching the trigger then she should go for it. It's a great pistol, I love mine.
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