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With this cartridge I think you would be well served to use published loads and using the exact components listed. We also have a good resource for 327 in the Handloader articles by Brian Pearce, so at least you know what has been tried off the books and professionally evaluated.
One thing I noted is that lead bullets I have used in Single Sevens will run well at full power with zero leading. I certainly don't get that with other calibers.
The limit on bullet weight seems to be around 100-115. Those originally intended for 32-20 run just fine and have a crimp groove. To go beyond that I bought some gas checked from Rimrock.
Seeing mention of flattened primers, I would offer that such should be expected with upper end loads in this cartridge. Consider though that tight throats will raise pressure and felt recoil, so being aware of throat size is important.
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Not an expert, just a reporter.
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