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I would not consider carrying a pistol with a safety that had to be pushed up to fire.
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To me this is an important part of the equation. Switching from a 1911 to a Glock when you are trained predominantly on a 1911 is no big deal as the Glock is a simpler platform. You are simply going to swipe at a safety that is not there.
Switching to a firearm with a radically different safety placement or direction of function would probably be a much different story.