I know several men in Wyoming that use the 45-70.
It's quite effective. The old black powder load of a 500 grain bullet and 70 grains of powder killed LOTS of buffalo in the 1870s-1880s so don't be afraid to used one. I'd recommend against the 300 grain hollow points, but all the bullets I am aware of from 350 to 550 are just fine, and any velocity from 1150 to 1900 will work, but going as fast as you can is really unnecessary.
1200-1500 is going to kill anything you hit, as long as you hit in the right place.
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