Well think about it. Check the weight of the 454 vs 45. Then figure you're not going hunting so you are probably only need to worry about an attack within 20 to 30'. Load up your choice with whatever you can handle and make a decision. I use my Governor loaded with 410 #6 up front and 255 hardcast as followups. I shoot to blind or hit the snout within 10' with the shot, and followup with the hardcast. But I'm not the norm, so hear out everyone and go where you feel comfortable.
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