Use a standard reamer for a 22-250. If you go with a short leade, you will not be able to seat your bullets out very far at first, but you are looking at 53 gr bullets so I'm not sure that is an issue. If you go with AI reamer, you will have fewer case stretching issues, but dies for 22-250 AI will cost you $160-$200, rather than the standard dies for $40 for standard 22-250. Also, be aware that with a 1:12" barrel, you will have to watch your loads carefully so you don't spin the bullets apart. I had that problem with a 1:14" barrel (28" barrel, I was hitting 4,000 fps with 50 gr bullets).
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