I've been using a 300 Winchester Mag since the early 90's as my elk rifle. I made the jump from a 30/06 because I witnessed an elk shot broadside in the heart with an ought six, 180 grain bullet, at about 250 yards, and the bullet was recovered. The elk ran over 100 yards and left very little blood to trail. In my mind then, and still today, is that 2 holes are better than 1 for tracking and that cartridge/bullet combination did not provide it at what I consider a very shootable distance.
So there you have it, I did not make the move to compensate for any bodily deficiencies
, I did it to make the job of recovering animals I shoot easier.