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Think in terms of volume instead of weight and you realize why a gun that could launch the bowling ball would probably take a faster powder.
"Slow" (relatively speaking) powders like H110 are good ways to accelerate a heavy 44 bullet down a long rifle barel. But the same powder is way too fast for the "faster" 243 Win.
The "faster" 243 starts with a larger case volume, and even though the lighter bullet accelerates faster, the small bore diameter requires a slower burn rate to maintain pressure as the bullet goes down the barrel.
That "slow" 243 powder in a smaller 44 Mag case wouldn't begin to maintain pressure as the "slower" 44 bullet traveled down the larger bore.
12 gauge loads may be even slower than the 44 mag, but the larger bore/smaller case has an appetite for even faster powders like Red Dot.
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