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I would get the 243. that's the cartridge I grew up with. I know the best ammunition for the job(for me anyways). I know it's limitations(which are pretty slim besides bullet weight) and I know exactly how comfortable I would be in taking an animal that is either smaller or larger than my targeted demographic.
all of this is based on personal experience mind you. I'm sure a 22-250 and a 260 are all very well suited to pretty much the same tasks but I'm just more familiar with the 243
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ignore my complete lack of capitalization. I still have no problem correcting your grammar.
I never said half the stuff people said I did-Albert Einstein
You can't believe everything you read on the internet-Benjamin Franklin
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