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Although my PX4 is the subcompact version, I'll chime in on this. My hands aren't very big, but I bought the PX4 because I found it very comfortable. My original intention was to buy the compact, but they were out of stock so I went with the sub instead and have been happy with it ever since. I honestly don't remember if I changed out the backstrap after buying it, or if the grip circumference is the same on the subcompact as on the compact.
However, liking the grip is one thing, but having long enough fingers for proper trigger access is another. This hasn't been a problem for me, and my wife shoots the PX4 (as well as larger semi-autos) just fine, but when you say "very small" hands, I would want to confirm overall finger reach and DA vs. SA trigger pull before spending the money.
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