I load my 300 grain XPTs over 20.4 grains of H110 on the bottom cannelure but that is for my SuperRedHawk.
I am probably being captain obvious here but a 300 XPT is going to penetrate any BG you are defending against and probably kill anyone standing behind them innocent or otherwise.
In my humble opinion, this might make an OK bear load and I use mine for deer but as a SD load I think you are way off base.
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