Either will do the job. Im bias to the 243. I used to be a bigger is better guy but have backed off that. I got my daughter a Tikka T3 in 243. Cut the stock down an 1" and added a limbsaver recoil pad. She shoots sub MOA with 90 gr Accubond bullets and has no problems dropping a deer in its tracks.
With any weapon if you shoot within the limits of the weapon and the shooter you will have no problems.
If she has a rifle she is comfortable shooting and and pick quality ammo the deer will fall. Just know your limits.
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