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Old January 17, 2020, 07:05 PM   #8
Ruger45LC
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Join Date: July 24, 2005
Location: Kentucky
Posts: 691
The performance would differ, the .40 could be considered deadlier because it pokes a bigger hole but a .22 100gr would have much higher sectional density than a .40 100gr, so it would definitely penetrate deeper. Their "energy" might be the same, but I'm not a big fan of relying on energy to determine effectiveness.
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