Assuming that you are referring to a .44 Magnum handgun for hunting game. In the instance of hunting something similar as a reindeer, the heavier bullet would be of little/no advantage. However, if hunting something larger i.e., Elk (European "Moose"), big bears, etc., then the heavier bullet would be deemed by many shooters to be better in terms of better penetration in heavier muscles, bones.
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