I would only recommend a semi-auto 22lr rifle under special circumstances, like recoil intolerance. Yes, any gun is better than no gun and 22lr can still be lethal.
But in your current situation, I would fort up in a room, preferably behind some stout furniture, with you shotgun loaded and pointed at the room entry point, and your 10/22 ready to scoop up, if the shotty can't do the job. Then call 911 and let the police clear your house.
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