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If you're going to go hot, what meatsaw said was good advice.
That said however, I wouldn't load your 200g LRN's very hot. You're going to run into leading problems. I've been loading .45 extensively since 1984. If it were me, I'd use the HP-38, and somewhere between 4.6 and 5.0 grains, and they'll still deliver decent spunk.
I'd save my Unique for .357 or jacketed .45's. Hell, I'd damn near trade my car for a pound of Unique right now lol.
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Gun control laws benefit only criminals and politicians - but then, I repeat myself.
Life Member, National Rifle Association
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