In my opinion, it is a bit too much cartridge. But.... my family does it anyway.
Our favorite bullet for "not-to-be-eaten" game is the Speer 100 grain hollow point. It stabilizes better than the 90 grain (for us), and still expands explosively. We have found IMR/H4895, IMR 4064, and H380 to all perform well. (I prefer H4895, but my brothers love the 4064 load.)
In 2000 or 2001, on a family prarie dog shoot in Wyoming; two of my brothers' .270 Winchesters claimed more prarie dogs than any other weapons in the group. Present were several .223s, my .220 Swift, a .375 H&H, a few 8x57s, a handful of 7.62x39s, and a lone .22 WMR. (Which sadly, also beat the .220 Swift that day; even on 200+ yard shots.)
The .270 Win and .270 WSM are too much cartridge. But, man is it fun to use them.
And for the record, I own a .243, .220 Swift, and .22 WMR; for varmints. The .270 is still more fun in most situations. (And allows you to practice with your hunting rifle, if it is the .270.)
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