Lungs, I'm a meat hunter and shoulder shots are a waste to me. As far as putting the quickest death, a deer with 3/4's of it's heart blown away by a 444 Marlin is a running dead animal for 100 yards. He just doesn't know it yet. A lung shot with just about anything, and he'll go for 30 - 50 yards. For a 30-06, I personally stay away from the fancy, high priced bullets. An 06 is standard velocity and a standard bullet is all that's needed IMO.
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There are three kinds of men:
1) The ones that learn by reading.
2) The few who learn by observation.
3) The rest of them have to pee on the electric fence and find out for themselves..........
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