Frequent comparison between the ME-262 and the F-80 come down to the weapons each plane had. As previously mentioned, the 262’s 30mm had a MV of about 1600fps. The F-80’s 50BMG was up close to 3,000fps if my math is correct.
If both planes were equal (and I don’t think they were) the pilot of the 262 would have to have been not only a better pilot but also a better shot.
The 30’s low velocity combined with a more than likely low ballistic coefficient would have resulted in a rainbow trajectory. Not the best time to be spending a lot of time estimating your enemies range. The high velocity 50 in my opinion would have been much more forgiving in these areas.
Some would argue that the 262 was built as a bomber destroyer which is true but it was what it was and I feel that the F-80, had they met, with its puny

50 cals would have cleared them from the sky, as well as bing able to shoot down any German bomber (had there been any)with ease.