Small point of terminology, the rear sight is screw adjustable. It is not "drifted" with a punch and hammer, or a sight pusher.
Call Colt, explain the situation and do as they advise.
I would suggest returning the sight to center and then shooting it again, and with as many different kinds of ammo as you can, and see where they hit. IF possible, have other shooters use it and see where they hit.
Then if things are off call Colt.
You can zero the gun within the available range of sight adjustment, so its not "defective", but its not an example of the good work that the Python reputation is built on. Even the new ones are banking on that name's reputation.
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All else being equal (and it almost never is) bigger bullets tend to work better.
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