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More information is required for the best advice...
Not clear on why you want to hot rod a 45 LC??? If you want something hotter, get a 44 Magnum or higher pressure round.
Your max load is what you work up to, starting from the lowest charge weight to the highest before you see signs of over pressure. That is the hottest load your gun can handle safely with that case, primer, powder and bullet combination.
Also, a big heavy pistol bullet like the 45 LC moving at 800 fps +/-, is a lot more capable vs most animals than many people realize.
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