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Now, as I said, I'm new to this, and I know I'm going to have to do batch testing with my own chronograph and targets to get actually test things, and it's not really a big deal, as I'm going to be target shooting with this. But, if I'm loading ammo for a SHTF situation for protection and all that good stuff, which one would be the better round? Or are there any other recommendations or things that I'm not thinking of at the moment. I would appreciate any help on this.
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We don't do SHTF here.
All bullets are lethal. The difference in terminal effects is at best, a measure of time for bleeding out for a "normal" hunting shot, and central nervous system hits will have identical effects.
The 300 BO doesn't have the energy to make a bullet fail on impact, so you penetration isn't a concern. Expansion is, as the BO has a pretty narrow impact velocity window with "normal" hunting bullets, which is why you see so many 110 to 125gr bullets marketed at the BO now.
So...load what you like to shoot. Your target loads are going to be "plenty lethal" if you need to use them for something other than target shooting.
Jimro