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As posted before in other posts, we've shot our .36 Pietta Remington with Swiss 4fg behind Kaido conicals with no problems. Charge weight was 1/10 of bullet weight or about 14-15 grains. No difference in accuracy compared with a full charge of 3fg but sure sounded cool.
The guns can take it. In 2012 Pietta tightened the twist on their .44s to handle the conversion cylinders shooting bullets, Uberti did this in 2007 with their Remington and went to forged frames.
Then there is the ROA, you can fill that chamber with smokeless powder and not blow it up according to Bill Ruger.
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“Gird up now thy loins like a man; for I will demand of thee, and answer thou me.” - Job 38:3
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