It really depends on the rifle in most cases. I've had a few that would put several loads into pretty much the same POI at 100 yards. At longer ranges heavier bullets would drop a little more, but that was easy to compensate for as long as you knew what was in your gun.
Other guns would not be close enough to try to use with more than 1 load. I have 1 rifle that if zeroed with 130 gr bullets will shoot 150's 2" right at 100 yards. If I zero it for the 150's, then the 130's are 2" left. I just picked one and don't try to use the other.