Learn your trajectory.Top of my head,a 100 gr bullet can be driven over 3000 fps within book handloads.
About 1.6 high at 100 would put you on at 200 and about 8 in low at 300.(Lots of variables here,I'm ballparking a general idea)
Put a 115 gr Nosler Ballistic tip in it,fine for deer and antelope to 300.
The .257 has been put in short actions,but you have to deep seat bullets.A 7x57 length Mauser action is just fine.