Caliber and bullet mass over velocity in my book, at least when we're talking heavy game and things use you for a chew toy. You do need enough velocity to drive the big heavy bullet through, from any angle.
'More than enough gun' is not a sin. I've had lots of .44 Mags and flirted with the 480, which I like a LOT. But when I pared my handgun battery down a few years ago, I kept the 45 Colt. I've used it in several guns; some take the heavy-hitters and some don't. I do have some 335 grain loads that run 1200 fps from my old Vaquero. But I am generally happy with a 255 grain bullet at 850 or 1050 fps, depending on the business at hand.
There is certainly nothing wrong with a good 44 Magnum.
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