Folks are slowly coming to the understanding that bullet mass has way more impact on lethality than velocity. All the .454, .460 and .500S&W gain you over slower cartridges is range. Heavyweight cast bullets at moderate velocities are more efficient and reliable killers than high speed jacketed pills. Now, you don't need a .475 or .500 to kill deer but when the critters get bigger, the greater diameter and mass of their bullets make them more consistently reliable on game. For these reasons, the .480Ruger deserves to be a far more popular cartridge than the X-frame monstrosities but S&W's marketing has been effective.
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I would imagine (guess?) that a 44Mag, loaded to slower velocities, but with it's bigger bullet, would be easier to handle vs a higher velocity 357.
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You would imagine right!