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I might suggest loading the biggest ".45" bullets that you can find. I have a S&W Hand Ejector Mk. II that was converted to .45 ACP via a new cylinder, but the bore is still way oversized for any bullets that will be found loaded in ACP cases.
I've handloaded .454" bullets with some success, but even those are undersized, and I don't know that bullets of any larger diameter will fit in the cylinder; that shouldn't be a problem for a gun originally chambered for larger bullets.
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