I take my home defense pistol with mounted light out of the safe when I come home in the evening and put it where I can get to it quickly, either next to my reading chair or upstairs on the night stand. When I go to work I take my carry gun with me and put the light-mounted pistol back in the safe.
I have considered one of the little gun vaults for next to the bed, but can't really justify it in light of the fact that the current arrangement works fine.
The United States Marine Corps: Providing the enemies of America the opportunity to die for their countries since 1775. Semper fi.