Ruger is notorious for making the holes in the cylinder different sizes.
Ruger is famous for accuracy in machining with their CNC equipment.
Pistols are hard to shoot accurately. I shot my Redhawk .44 mag. competitively, and did well, for many years. Shoulder injuries took me away from that for about five years. When I tried again I couldn't hit a barn wall, from the inside. It takes much practice to get back again, even from a rest. Try going to 25 yards, that will tell you much about yourself and the gun.
Clean and de-lead bore and cone.
Remove scope and have it checked. My .44 mag. has ruined an Aimpoint and a scope with recoil.
Really, there is no reason why it shouldn't shoot fine.