I use a 77/22 with the premium CCI ammo. I am not a huge fan of stingers but I love the Velocitors. I also used a Henry Golden boy until it was out of my truck.
I save the bulk stuff for shooting cans and such.
I also find a 12ga with cheep target loads and a full choke work well (as long as you are not going to be eating or skinning them).
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...