I Carry my 640 in 357 magnum, my wife carries a P238 in 380acp.
To be honest carry what you like and practice with what you carry.
Shot placement is everything! I would rather take a round of 50BMG to the foot than a 22short to the base of the skull.
all 26 of my guns are 45/70 govt, 357 mag, 22 or 12 ga... I believe in keeping it simple. Wish my wife did as well...