The 380 has limits as does any handgun round. If you know those limits and train / think around those then it's a reasonable choice esp. In the "pocket gun" market.
There is a tendency to worst worst case everything when it comes to defensive caliber selection which quickly leads to the 380 being tossed out as no good. As others have mentioned if I had to face down some nut on bath salts I would much prefer a 12 gauge or 1911, however what I may well have is a 7 shot 380 due to it's size and ease of carry.