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I use Blue Dot in a bolt action 308 Win. that has a 22" 1:12 twist barrel, with a Nosler 125gr BT and Federal 210 primer and 16gr of BD is about a 50% case fill.
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Seafire seems to be the starting point for Blue Dot loads in 223 and it appears it is spreading to other calibers.
I called Alliant and asked their opinion. They don't publish Blue Dot in 223 loads because small changes in components, chambers, result in big spikes in pressure. The powder is too sensitive in these applications.
I looked at my old Hercules manuals, no Blue Dot loads in 308/30-06, and I am of the opinion it is for the same reason.
On this site there is a picture of a 257 Weatherby that was blown using reduced charges of Blue Dot.
http://thefiringline.com/forums/showthread.php?t=341348 The poster of which thought it was due to his double charging reduced loads of Blue Dot, which would be reasonable culprit if the powder was appropriate to the application. But given the known issues around Blue Dot's pressure curve, it is more likely that the load was not double charged but blew because of Blue Dot's sensitivity to components and conditions.
I would not hand my kid a rifle stuffed with one of these time bombs. Just look at the pictures and decide for yourself.