But would the Glock be that much less accurate at (let's say) less than 50 yards?
Mechanically? No. Practically? Maybe. The single action trigger pull of that revolver will be much lighter than the 5.5lb Glock factory pull. If you lighten the trigger, add a KKM or Storm Lake 6'' barrel, and change the sights you can get awesome accuracy out of a 10mm Glock. With the gun below, the best shooter I know hit a bowling pin 5 out of 6 shots with 155gr Gold Dot Underwood ammo at 100m. (I can't do this but he did--very impressive)