Love the .22's
Smith & Wesson 22A . . . . my workhorse with many thousands of rounds through it.
Beretta NEOS INOX with 4.5" barrel . . . . my favorite and my league gun
Beretta NEOS black with 6 barrel . . . . . bought for leagues but just didn't like it as well as the 4.5" INOX
Buckmark Camper with SS 6" barrel . . . . my sons league gun
Ruger Mark III 22/45 . . . . because you have to have a Mark II or III
Walther P22 . . . . just because it's cool (albeit finicky, I may get a Mosquito some day too
A better question to me is what 22 handguns do you actually shoot?
All of them, but the 22A, the 4.5" NEOS, and the Buckmark get the most range time.