What fiddletown said times two
It was a common carry round before the media brain washed everyone into thinking only a cannon will do the job.
Read what Fiddletown said. If that doesn't allow you to understand why the 22lr is the worst defensive caliber choice available then stop debating because nothing will change on either side.
The media didn't brainwash me and I guarantee it didn't brainwash Fiddle. It really isn't rocket science to get it. A 45 caliber 12 inch deep wound is better than a 22 caliber 10 inch wound. A 45 cal 230 grain bullet at 950 feet per second will smash a blocking bone and continue to dig deeper into the body than a 22 caliber 40 grain bullet at 1300 fps will.
Its a simple as that.