I don't know why this is always an issue? This has been going on for a century or longer, and dangerous game loads are a known quantity, so why argue? It is not magic or rocket science.
.45 Caliber, quality bullets, no matter what name you call it, 45/70, 450 Marlin, .458 Win. Mag., 458 Lott, all work well within reasonable loadings!
This is proven in the field, not at the kitchen table with a glass of scotch, but it could be debated there!!!