Depending on your barrel length, R-22 is my top choice for bullets of 100 gr. or over, and a 26" barrel...or longer. IMR-4831 is a top pick for lighter bullets, shorter barrels, or both. Knock on wood...I've never seen a 25-06 that didn't love IMR-4831. Some swear by IMR-4350, but the '25 thrives on slower burning powders; if you want speed and accuracy, that tends to leave out the faster burning powders.