Well put Pilgrim. I guess the OP was mostly interested in the hotter faster loadings, but you're missing out if you don't investigate the more moderate loads as well. I like the 44 mag and 357 mag because there is a lot of room to play with there. The one powder that I know of that deviates from the normal worries about fast powders/big cases is Tite Group. I don't understand the chemistry there, but Tite Group works extremely well in big cases with low charge levels. It burns clean and consistently with just a little dab of it in the case. It gives some pretty respectable loads in my 44 mag revolvers. Not in the w296 range, but surprisingly high anyway. I have even loaded Tite Group in my 480 Ruger loads. Not the obvious choice, but it worked very well for some pretty potent, highly accurate, clean burning loads.
I just went and counted the pistol powders in the closet again. Hmm... 15 of them in there and there's a couple more that I'd like to have. I LIKE having 15 of them, but I could still function with 3 or 4. Don't ask me which ones I would have to eliminate, but if I was forced to cut down on the number of powders, I think I would definitely have a can of 2400 and a can of Tite Group on the shelf no matter what.
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