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S&W did an 18,000 round test in the 90s using full power Norma ammunition. They stopped at 18,000 rounds because the gun didn't break and the frame didn't crack. The gun can take the ammo it was designed to handle.
I load a ton of 10mm.
Your powders you want for full power (no such thing as +P 10mm) are #9 or Longshot. 800X meters like crap. It has also been known to blow up guns due to it's finicky pressure curve. That's why Hodgdon removed the 135gr/800X data from the manual when they took over IMR powder distribution.
Longshot is a reformulated HS7 and is excellent for the 10mm. Nearly ideal.
#9 is a great powder, meters like water due to it's sand grain ball engineering. Ball powders are not compressible, BTW. Try pushing down on a jar of marbles. Same thing.
Blue Dot is another good powder and was the first one I tried when I started handloading on the Lee hand press. Similar burn rate as #9 but being a flake powder it doesn't meter as well, but still accurately enough for the 10mm. You might get .1gr variation in a Dillon or RCBS type powder measure but that's pretty OK.
For range loads, WSF, HS6, or #5 will do just fine. WSF is my recommendation for lead loads as it burns clean, give great velocity, and won't smoke as much as others.
Those powders mentioned are all you need for the 10mm. If I were to keep two powders on the bench, they would be Longshot and WSF. Longshot for heavy loads and WSF for lead and range loads.
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