I wouldn't do it simply because the black powder residue will get into the works of the gun, and will be a PITA to clean. If you don't clean with BP solvents or good old hot soapy water, everywhere the fouling lands, it will rust on you. Not worth it with a modern gun. I do load 45LC with BP. I use 30 grains FFFg (volume), one lubed felt wad, and a 250 grain LRN bullet with 50/50 beeswax/crisco hand squished into the lube groove. Works well for me in a '58 remi replica. I've recently taken to loading 45lc with trailboss at cowboy action pressures. Lot's easier to clean and way more shooting before needing cleaned. No fouling binding up the works.
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