The first single action I ever owned was a .45 colt. Loved that gun. That was about 17 years ago. I bought my first .44-40 13 years ago. I have since bought 5 more .44-40 firearms. I have seen no difference between the two. I have taken several deer with my .44s. Rifle and revolvers. I have never had a hard time finding >44-40 ammo. Besides you can always order it. Sorry for the long post but I love my .44s