Not just a whole bunch. The .45 colt uses a heavier bullet . Running both rounds at 750 to 950 feet per second the 44-40 with give less recoil. Since you already have a .45 get the .44 .You can always trade it if you don't like it.
One suggestion, if possible mic the chamber throats on the gun you plan to buy. Oversize or undersize throats can cause bad accuracy.
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