There's a couple ways to save a teeny bit of money that would go further than shaving two tenths of a grain on powder per round.
First would be to pick a different powder. Compare the charges of Unique with AA#2 or 231 or Bullseye or Power Pistol across the same caliber and you can see quickly is many calibers how some powders simply use a smaller charge weight... lower charge weight obviously means more loaded rounds per pound.
If you buy your powder in a 4 or 8 pound can, you'll save more money than shaving 0.2 grains from a single loaded round. If you buy your powder from someone who sells powder MUCH cheaper than your local shop, you can also save a heap, much more than 0.2 grain per round.
If you use a lighter bullet (and it's still acceptable for the task), you'll need a bit more powder to send it to the target, but you can typically save a good bit on your bullet costs. In .45, compare 500 rounds of 185 gr with 500 rounds of 230 grain.
If you ever get in to bullet casting, you can save more money than getting your powder for free! Casting is not for everyone, though.
Theoretically, you could increase pressure by seating deeper, but as it was said, it's not a linear thing. And you need to make sure you ammo feeds and you case mouth tension is up to the task.
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